Anti-phospho-Caspase 8 (pTyr380) antibody produced in rabbit, approx. 1 mg/mL, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Caspase-8 (CASP8) is involved in apoptosis, inflammation and cellular differentiation. It activates programmed cell death, after death receptor ligation. Casp8 is essential for the clonal expansion of T and B cell. It also participates in lymphocyte homeostasis.

Disclaimer

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Features and Benefits

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General description

Caspase-8 (CASP8) is a member of the cysteine aspartate-specific proteases family. It is produced in the cell as procaspase-8, a sluggish zymogen. Procaspase-8 has a long prodomain, carrying two major protein interaction domains, DED₁ and DED₂, followed by one large (p18) and one small (p10) catalytic subunit. CASP8 is mapped to human chromosome 2q33.

Immunogen

The antiserum was produced against synthesized peptide derived from human Caspase 8 around the phosphorylation site of Tyr380.Immunogen Range: 346-395

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.