Anti-phospho-MEK1/2 (pSer221) antibody produced in rabbit, approx. 1 mg/mL, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Biochem/physiol Actions

MAP2k1/2 (dual specificity mitogen-activated protein kinase kinase 1/2) is a serine threonine kinase and is required for ERK (extracellular-signal-regulated kinase) activation. Activation of ERK is associated with production of IL-10 (interleukin 10) and IL-12. Absence of the Map2k1 gene results in embryonic lethality. Map2k1 is responsible for the stimulation of epidermal proliferation, regulating cell migration in fibroblasts. Deficiency of Map2k1 protein causes lupus-like syndrome. The gene encoding Map2k1 is localized on human chromosome 15q22.31 and the MAP2K2 gene is localized on human chromosome 19p13.3.

Features and Benefits

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Immunogen

The antiserum was produced against synthesized peptide derived from human MEK1/2 around the phosphorylation site of Ser221.Immunogen Range: 193-242

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.