Anti-phospho-CD4 (pSer433) antibody produced in rabbit, approx. 1 mg/mL, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Biochem/physiol Actions

CD4 (CD4 molecule) helps in the activation of immunostimulatory T-cells. It serves as a primary receptor for HIV-1 entry. Individuals with infectious and chronic inflammatory diseases shows higher level of soluble CD4 (sCD4).

Features and Benefits

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General description

CD4 (CD4 molecule) is present in the surface of specific leukocytes. CD4 contains four ecto-domains (D1-D4) of which D1, D2, and D4 contain disulfide bonds. It is mapped to human chromosome 12p13.31. CD4 belongs to the immunoglobulin superfamily (IgSF). It has four extracellular Ig-like domains, a hydrophobic transmembrane region and a 40-residue cytoplasmic tail.

Immunogen

The antiserum was produced against synthesized peptide derived from human CD4 around the phosphorylation site of Ser433.Immunogen Range: 401-450

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.