Anti-phospho-BTK (pTyr551) antibody produced in rabbit, approx. 1 mg/mL, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Bruton tyrosine kinase (BTK) is a key element of B-cell–receptor signaling, which facilitates interactions with the tumor microenvironment and stimulates the survival and proliferation of chronic lymphocytic leukemia (CLL) cells. The encoded protein also plays a crucial role in activation of various constitutively active pathways of CLL-cell survival, such as the Akt, extracellular signal-regulated kinase (ERK) and nuclear factor κ light-chain enhancer of activated B cells (NF-κB) pathways. Additionally, it is also necessary for chemokine-mediated homing and adhesion of B cells. Polymorphisms in the gene are associated with the development of a symptomatic primary antibody deficiency (PAD), X-linked agammaglobulinemia.

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General description

Bruton tyrosine kinase (BTK) is encoded by the gene mapped to human chromosome Xq22. The encoded protein belongs to the Tec family of kinases.

Immunogen

The antiserum was produced against synthesized peptide derived from human BTK around the phosphorylation site of Tyr551.Immunogen Range: 516-565

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.