Anti-phospho-Smad1 (pSer465) antibody produced in rabbit, approx. 1 mg/mL, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Biochem/physiol Actions

SMAD (homologues of the Drosophila protein, mothers against decapentaplegic (Mad) and the Caenorhabditis elegans protein Sma) proteins have a major role in disease development and hence act as biologic prognostic factors in diseases. miR-345 represses the multiplication, invasion and migration of prostate cancer by downregulating Smad1.

Disclaimer

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General description

Smad1 (SMAD family member 1) is a transcriptional activator, that is located on human chromosome 4q31.

Immunogen

The antiserum was produced against synthesized peptide derived from human Smad1 around the phosphorylation site of Ser465.Immunogen Range: 416-465

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.