ANTI-IGFBP-3 ANTIBODY PRODUCED IN RABBIT

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Insulin-like growth factor-binding protein 3 (IGFBP3) can stimulate cell growth and apoptosis. It participates in DNA repair. Patients with rheumatoid arthritis show an increased level of IGFBP3 in the serum and synovial fluid. It is involved in the proliferation of stress-induced senescence in human endometrium-derived mesenchymal stem cells (MESCs). IGFBP3 can suppress insulin-like growth factor-1 (IGF-1) signaling and modulate lung carcinogenesis and cell proliferation.

Disclaimer

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Features and Benefits

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General description

Insulin-like growth factor-binding protein 3 (IGFBP3), a multifunctional protein belongs to the insulin-like growth factor binding proteins (IGFBPs) superfamily. The IGFBP3 gene is located on human chromosome 7p12. Anti-IGFBP-3 antibody detects endogenous levels of total IGFBP-3 protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human IGFBP-3.Immunogen Range: 151-200

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.