Anti-Catenin-beta antibody produced in rabbit, approx. 1 mg/mL, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Mutations in β-Catenin results in retinal vascular condition FEVR (familial exudative vitreoretinopathy). It participates in stimulating disease progression, providing to BCR–ABL (fusion gene) kinase-independent resistance and LSC (leukemic stem cell) self-renewal. It plays an important role in cell-to-cell adhesion and transcriptional modulation in the Wnt signalling pathway.

Disclaimer

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Features and Benefits

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General description

Anti-Catenin-β Antibody detects endogenous levels of total Catenin-β protein.

Catenin-β is a multifunctional protein, coded by CTNNB1 (catenin β 1) gene. It is present in the intracellular side of the cytoplasmic membrane. It is located on human chromosome 3p22.1.

Immunogen

The antiserum was produced against synthesized peptide derived from human Catenin-beta.Immunogen Range: 455-504

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.