ANTI-ASH2L

Not available outside of the UK & Ireland.

Features and Benefits

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General description

The antibody detects endogenous level of total ASH2L protein.

Immunogen

Peptide sequence around aa. 620-624 (G-R-R-S-P), according to the protein NP_004665.2

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Target description

Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates ′Lys-4′ of histone H3, but not if the neighboring ′Lys-9′ residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ′Lys-4′ of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.