ANTI-ASPSCR1

Not available outside of the UK & Ireland.

Features and Benefits

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General description

The antibody detects endogenous levels of total ASPSCR1 protein.

Immunogen

Peptide sequence around aa. 303 -307 (P-Q-Q-E-Q), according to the protein NP_076988.1

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Target description

Tug (Tether containing UBX domain for GLUT4), also known as ASPL, ASPSCR1, RCC17, UBXD9, UBXN9, was first identified as a chromosomal translocation partner for TFE3 in patients with Alveolar soft part sarcoma and contains an UBX-like domain in its C-terminal region. Tug is found to tether GLUT4 in intracellular vesicles and to release GLUT4 for cell surface translocation upon insulin stimulation . Stable Tug depletion or expression of a dominant negative form stimulates GLUT4 redistribution.