Anti-Snca (Ab-136) antibody produced in rabbit, affinity isolated antibody

Not available outside of the UK & Ireland.

Disclaimer

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Features and Benefits

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Immunogen

Peptide sequence around aa. 134-138 (Q-D-Y-E-P), according to the protein Snca.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Target description

May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.