Anticorps Anti - MAPT (Ab -356)produit dans un anticorps isolé rabbit affinity

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Removal of MAPT results in developmental delay and learning disability. It participates in the pathology of Alzheimer′s disease (AD). It helps in the assembly and maintenance of microtubule structure.

Features and Benefits

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General description

MAPT (microtubule associated protein tau) is located on human chromosome 17q21.3. It is upregulated in neurons but is most prominent in axons.

Immunogen

Peptide sequence around aa. 354-358 (I-G-S-L-D), according to the protein MAPT.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Target description

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.