Anti-ERBB2 (Ab-1221/1222) antibody produced in rabbit, affinity isolated antibody

Not available outside of the UK & Ireland.

Biochem/physiol Actions

ERBB2 (erb-b2 receptor tyrosine kinase 2) is considered as a therapeutic target in breast cancer. It controls the concentration of intracellular calcium in SKBR3 (breast cancer cell line) cells.

Disclaimer

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Features and Benefits

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General description

ERBB2 (erb-b2 receptor tyrosine kinase 2) is a tyrosine kinase receptor that belongs to the ErbB family. It is also known as HER2/Neu. It is located on chromosome 17q12.

Immunogen

Peptide sequence around aa. 1219-1223/1220-1224 (N-L-Y-Y -W), according to the protein ERBB2.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Target description

Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.