Anti-phospho-PRKCD (pSer645) antibody produced in rabbit, affinity isolated antibody

Not available outside of the UK & Ireland.

Features and Benefits

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Immunogen

Peptide sequence around phosphorylation site of serine 645 (R-L-S(p)-Y-S), according to the protein PRKCD.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Target description

This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May play a role in antigen-dependent control of B-cell function. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin.