Anticorps Anti - phospho - AR (pSer213) produit dans un anticorps isolé rabbit affinity

Non disponible en dehors du Royaume-Uni et de l'Irlande

Disclaimer

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Features and Benefits

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Immunogen

Peptide sequence around phosphorylation site of serine 213 (E-A-S(p)-G-A), according to the protein AR.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Target description

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: theN-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormoneactivated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins,translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This genecontains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in theN-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscularatrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Twoalternatively spliced variants encoding distinct isoforms have been described.