Anti-phospho-MAPT (pSer396) antibody produced in rabbit, affinity isolated antibody

Not available outside of the UK & Ireland.

Disclaimer

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Features and Benefits

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Immunogen

Peptide sequence around phosphorylation site of serine 396 (Y-K-S(p)-P-V), according to the protein MAPT.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Target description

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.