Anti-phospho - GATA1(pSer310) anticorps produit dans un anticorps isolé rabbit affinity

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

GATA binding protein 1 (GATA1) plays a crucial role in erythroid and megakaryocyte differentiation and proliferation. It modulates the expression of genes and acts as an E-cadherin repressor. Mutations in the GATA1 gene have been linked to transient abnormal myelopoiesis (TAM) and myeloid leukemia of DS (ML-DS). The protein has anti-apoptotic functions in breast cancer.

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General description

GATA binding protein 1 (GATA1) is a key hematopoietic transcription factor. It is encoded by the gene mapped to human chromosome Xp11.23 and it belongs to the GATA transcription factor family.

Immunogen

Peptide sequence around phosphorylation site of serine 310 (K-A-S(p)-G-K), according to the protein GATA1.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Target description

GATA1 encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia.