Anti-TFRC antibody produced in rabbit, approx. 1.0 mg/mL, affinity isolated antibody

Not available outside of the UK & Ireland.

Application

Anti-TFRC antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Biochem/physiol Actions

Transferrin receptor (TFRC) mediates cellular iron uptake. It binds iron bound transferrin on the cell surface, and the receptor ligand complex undergoes endocytosis via clathrin coated pits. Endosomal acidification leads to iron release, which is transported to the cytosol or to the mitochondria in erythroid cells. The apotransferrin receptor complex is then recycled to the cell surface, where the affinity of apotransferrin for TFRC drops, resulting in its dissociation. TFRC is necessary for development of erythrocytes and the nervous system.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Transferrin receptor (TFRC), also known as p90, CD71, TFR and TFR1, is a transmembrane glycoprotein. It is composed of two disulphide-bonded sub-units, contains three N-linked glycan units and is post-translationally modified with phosphate and fatty acyl groups.

Immunogen

synthetic peptide corresponding to an internal sequence of human TFRC, conjugated to KLH

Physical form

solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide