MONOCLONAL ANTI-NECTIN-4 PVRL4+

Not available outside of the UK & Ireland.

Application

Monoclonal Anti-PVRL4 antibody produced in mouse has been used in immunocytochemistry and flow cytometry.

Biochem/physiol Actions

Nectin-4 is involved in cell adhesion through trans homophilic and heterophilic interactions. Mutations in this gene are associated with ectodermal dysplasia-syndactyly syndrome type 1.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Monoclonal Anti-Nectin-4/PVRL4 (mouse IgG1 isotype) is derived from the hybridoma R2.525.2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with human nectin4-Fc recombinant protein. Nectin-4 belongs to the family of Nectins. It forms homo-cis-dimers and then homo- or hetero-trans-dimers through the extracellular region in a Ca²⁺-independent manner. Nectin-4 is expressed in placenta, ductal breast carcinoma and lung adenocarcinomas. It is one of the plasma membrane components of adherens junctions.

Immunogen

human Nectin4/Fc recombinant protein

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.