Anti-Tensin 1 (C-Terminal Region)

Not available outside of the UK & Ireland.

Application

Anti-Tensin 1 (C-terminal region) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Biochem/physiol Actions

Tensin 1 plays an important role in regulating cell polarization, shape, motility and invasion. Tensin 1 is cleaved by calpain II, a focal adhesion protease, suggesting that tensin 1 plays important roles in organizing the actin cytoskeleton and mediating signal transduction.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Tensins are a new family of focal adhesion proteins that link between the extracellular matrix (ECM) and the cytoskeleton via integrins. The tensin family includes four members: tensin1-4, encoded by different genes. Tensins are multidomain proteins consisting of homologous C1, protein tyrosine phosphatase (PTPase), C2, SH2 and PTB domains. Tensin 1 (also known as TNS1), shares extensive homology with tensin 2 and tensin 3 at its N- and C-terminal regions. Tensin 1 mRNA is broadly expressed in mouse embryo and various human tissues and is localized to focal adhesions.

Immunogen

synthetic peptide corresponding to a sequence located near the C-terminus of human tensin1, conjugated to KLH. The corresponding sequence is identical in rat and mouse tensin1.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.