Anti-SRGAP3 antibody produced in rabbit, approx. 1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

Anti-SRGAP3 antibody produced in rabbit has been used in immunofluorescence and immunoblotting.

Biochem/physiol Actions

SRGAP3 (Slit-ROBO Rho GTPase-activating protein 3) negatively regulates cell migration, by inhibiting the activity of Rac1 and Cdc42. SRGAP3/MEGAP has been associated with severe mental retardation in several patients. It plays pivotal roles in learning and memory. SRGAP3/WRP interacts directly to WAVE-1 through its Src homology domain and specifically inhibits Rac function in vivo.Induced expression of SRGAP3 inhibits Rac1 and Cdc42 activity and impedes cell migration by impairing actin and microtubule dynamics and formation of focal complexes.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Anti-SRGAP3 is produced in rabbit using as the immunogen a synthetic peptide corresponding to a fragment of human SRGAP3 (GeneID: 9901), conjugated to KLH. SRGAP3 (Slit-ROBO Rho GTPase-activating protein 3, also known as MEGAP, is a GTPase activating protein, that belongs to the Slit-ROBO GAPs (SRGAPs) family. It is predominantly expressed in the brain during embryonic development and in the adult brain, specifically in neurons of the hippocampus and cortex. SRGAP3 exists as two isoforms SRGAP3A and SRGAP3B.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.