Anti-LIMP2 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

Anti-LIMP2 antibody produced in rabbit has been used in immunofluorescence(1:100) and western blotting.

Biochem/physiol Actions

Lysosomal integral membrane protein type 2 (LIMP2) binds to β-glucocerebrosidase. Mutations in the LIMP 2 gene are associated with action myoclonus-renal failure syndrome, a fatal autosomal recessive disorder. Higher levels of LIMP2 lead to enlargement of early or late endosomes/lysosomes. Overexpression of LIMP2 is associated with impairment of endocytotic membrane trafficking.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Lysosomal integral membrane protein type 2 (LIMP2) is an N-glycosylated type III transmembrane protein. It is composed of a lumenal domain, twotransmembrane domains, and a cytoplasmic domain. LIMP2 belongs to theCD36family ofscavenger receptorproteins and is found abundantly in the lysosome. The LIMP2 gene is located on the human chromosome at 4q21.1.

Immunogen

LIMP2 antibody was raised against a 16 amino acid peptide from near the center of human LIMP2.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500449.

Physical form

Supplied in PBS with 0.02% sodium azide.