Anti-Clusterin antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

Anti-Clusterin antibody produced in rabbit has been used in immunohistochemical (IHC) staining (1:1,000 & 1:100).

Biochem/physiol Actions

Clusterin (CLU) is a multifunctional plasma protein and a fluid-phase complement inhibitor. It mediates the complement terminal pathway. Clusterin is an ATP-independent small heat shock protein-like chaperone. It functions as a redox sensor and a lipid transporter. Clusterin is associated with many age-related diseases such as neurodegeneration and metabolic syndrome. It is involved in cancer progression, promotion, metastasis, and chemoresistance. Increased serum CLU levels are observed in type 2 diabetes (T2D). It is known to suppress proteotoxicity. Clusterin might show anti or proapoptotic activities. This protein is associated with different functions of the brain. A single nucleotide polymorphism (SNP) in the CLU gene might cause the development of late-onset Alzheimer′s disease (LOAD).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

The Clusterin (CLU) gene is mapped to human chromosome 8p21.1. The encoded protein is a chaperone and is conserved along with evolution. It is present in human tissues and fluids.

Immunogen

Clusterin antibody was raised recombinant human Clusterin isoform 1.

Physical form

Supplied in PBS with 0.02% sodium azide.