Anti-CDIP antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution, ab2

Not available outside of the UK & Ireland.

Features and Benefits

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Immunogen

CDIP antibody was raised against a 19 amino acid peptide near the center of human CDIP.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500011.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Target description

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway. CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.