Anti-TICAM1/TRIF (AB1) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Toll like receptor adaptor molecule 1 (TICAM1) plays a crucial role as an adaptor molecule and links toll-like receptor 3 (TLR3) to interferon-β (IFN-β) promoter activation. It is also involved in IFN-β production. TICAM-1 pathway has an essential role in host protection and innate immune responses against poliovirus (PV) infection. Mutations in the gene have been associated with the development of papillary thyroid cancer, follicular thyroid cancer and differentiated thyroid cancer.

General description

Toll like receptor adaptor molecule 1 (TICAM1) is ubiquitously expressed and possesses an N-terminal proline-rich domain, a TIR (Toll/interleukin-1 receptor) motif and a C-terminal proline-rich domain. The gene encoding this protein is localized on human chromosome 19p13.3.

Immunogen

Synthetic peptide from human TICAM1 / TRIF.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide.