Monoclonal Anti-ESR2 antibody produced in mouse,

Not available outside of the UK & Ireland.

Application

Suggested starting dilutions are as follows: Dot: Assay-dependent dilution, FACS: Assay-dependent dilution, ICC/IF: Assay-dependent dilution, IHC: Assay-dependent dilution, IHC-P: Assay-dependent dilution, WB: 1:1000-1:10000, ChIP assay: Assay-dependent dilution. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Biochem/physiol Actions

The human ER-beta is a newly discovered estrogen receptor initially cloned and characterized from testis. The size and structure of ER-beta is very similar to ER-alpha with the ligand and DNA binding domains being highly conserved, while the amino terminus which serves as their transactivation domain has diverged significantly. Similar in function to ER-alpha ER-beta binds to estrogen with a high affinity and regulates estrogen specific gene activation through direct interaction with estrogen response elements (ERE′s).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Immunogen

Amino acids 1-153 of human ER-beta expressed in E. coli.

Physical form

Phosphate-buffered saline, no preservative added.