Anti-SUMF1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Sulfatase modifying factor 1 (SUMF1) converts a highly conserved cysteine in the catalytic domain of sulfatase to form C α-formylglycine (FGly) by post-translational modification. Mutations in the gene encoding this protein have been associated with multiple sulfatase deficiency.

Disclaimer

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General description

Sulfatase modifying factor 1 (SUMF1) or formylglycine-generating enzyme (FGE) is a 41kDa glycoprotein. It is localized at the lumen of the endoplasmic reticulum. The protein consists of an amino-terminal domain and a core domain with the active site. The gene encoding SUMF1 is localized on human chromosome 3p26.1 and contains nine exons.

Immunogen

Peptide with sequence CETLNPKGPPSGKDR, from the internal region of the protein sequence according to NP_877437.2.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.