Anti-PPP1R15A/GADD34 antibody produced in goat, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) recruits and regulates the α-subunit of protein phosphatase 1 (PP1). It functions as a stress marker. When there is depletion in amino acid levels in the cell, PPP1R15A is expressed in high concentrations. It regulates the mammalian target of rapamycin (mTOR) pathway and thereby boosts autophagy in macrophages. Studies have shown that PPP1R15A is expressed in the oligodendrocytes of patients suffering from Alzheimer’;s disease.

Disclaimer

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General description

Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) or growth arrest and DNA-damage-inducible 34 (GADD34) is the regulatory subunit of eukaryotic translation initiation factor 2 (eIF2α) phosphatase. It is expressed when there is a signal indicating endoplasmic reticulum stress. The PPP1R15A gene is localized on human chromosome 19q13.33.

Immunogen

Peptide with sequence C-AAALDLSGRRG from the C Terminus of the protein sequence according to NP_055145.2.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.