Anti-Pancreatic polypeptide/PPY antibody produced in goat, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

Anti-Pancreatic polypeptide/PPY antibody produced in goat has been used in immunohistochemistry and immunofluorescence.

Biochem/physiol Actions

Pancreatic polypeptide (PPY) or PP has glucoregulatory functions. It modulates biliary secretion and food digestion by preventing gastric emptying. PPY binds to the Y4 receptor and has a role in increasing the number of insulin receptors on hepatocytes. The protein has been associated with chronic pancreatitis and pancreatogenic diabetes. PPY also negatively regulates the expression of resistin hormone.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Pancreatic polypeptide (PPY) or PP is an endogenous peptide hormone. It is secreted by the PP cells of the Islets of Langerhans, in the pancreas. PPY is part of the neuropeptide Y family of hormones. It is a 36 amino acid proteinand the gene encoding it is localized on human chromosome 17q21.31.

Immunogen

Peptide with sequence C-TRPRYGKRHKEDT from the internal region of the protein sequence according to NP_002713.1.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.