Anti-GPR40 antibody produced in goat, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Biochem/physiol Actions

G protein-coupled receptor 40 (GPR40) maintains insulin and glucose homeostasis. It plays an important role in the development of type 2 diabetes. GPR40/FFA1 signaling may participate in the regulation of endogenous pain control systems. It is considered as an anti-diabetic drug target.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

G protein-coupled receptor 40 (GPR40) belongs to the G protein-coupled receptors. It is a 300 amino acid protein, that has seven characteristic transmembrane domains. GPR40 is also known as FFA1 (free fatty acid receptor 1). It is expressed in the β cell of the pancreas, spinal cord and brain. It is located on human chromosome 19q13.

Immunogen

Peptide with sequence CAARTQGGKSQK from the C Terminus of the protein sequence according to NP_005294.1.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.