Anti-APOB antibody produced in goat, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

Anti-APOB antibody produced in goat has been used in enzyme-linked immunosorbent assay (ELISA).

Biochem/physiol Actions

Apolipoprotein B (APOB) participates in human lipoprotein metabolism. APOB-48 plays an essential role in the synthesis of chylomicron. APOB-100 is required for the structural component of very-low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), and low-density lipoprotein (LDL). APOB is essential in the molecular diagnosis of familial hypercholesterolemia (FH). The hydrophobic lipid-binding and hydrophilic regions are capable of interacting with the aqueous plasma environment.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Apolipoprotein B (APOB), a large amphipathic glycoprotein, has hydrophobic lipid-binding and hydrophilic regions. It has a low-density lipoprotein (LDL)-receptor-binding domain. The APOB gene with 29 exons produces two forms, such as apoB-48 and apoB-100 in circulating lipoproteins. This gene is located on human chromosome 2p24.1.

Immunogen

Peptide with sequence C-TDLHLRYQKDKK from the internal region of the protein sequence according to NP_000375.2.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.