Anti-AIF1/IBA1 (Isoform 3) antibody produced in goat, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

Anti-AIF1/IBA1 (Isoform 3) antibody produced in goat has been used in western blotting and immunofluorescence.

Biochem/physiol Actions

AIF1 (allograft inflammatory factor 1) is an essential factor of macrophage chemotaxis. Expression of AIF1 regulates the proliferation of vascular smooth muscle cells by G-CSF (cytokine granulocyte-colony stimulating factor) autocrine expression.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

AIF1 (allograft inflammatory factor 1) is a calcium-binding, cytoplasmic protein that has 143-amino acids. It is also known as IBA1 (ionized calcium-binding adapter molecule 1). It is expressed in the cells of the monocyte/macrophage lineage, as well as in microglial and dendritic cells. It is located on human chromosome 6p21.3.

Immunogen

Peptide with sequence C-NKQFLDDPKYSSDED from the internal region of the protein sequence according to NP_001614.3.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.