ANTI-KLHL36

Not available outside of the UK & Ireland.

General description

The gene KLHL36 (kelch like family member 36) encodes a member of the Kelch-like (KLHL) protein family, the members of which contain a BTB/POZ (Broad-Complex, Tramtrack and Bric a brac/ POxvirus and Zinc finger) domain, a BACK (BTB and C-terminal Kelch) domain, and five to six Kelch motifs. The BTB domain participates in protein association and dimerization. The kelch domains form a tertiary structure of β-propellers that function in several extracellular processes, such as morphology and protein association. The function of the BACK domain is yet to be characterized. However, mutations in this domain are associated with disease. Around 42 KLHL genes have been identified across multiple human chromosomes. The encoded protein is 616 amino acids long.

Immunogen

KLHL36 (NP_079007.2, 1 a.a. ~ 616 a.a) full-length human protein.SequenceMMEGSRQTRVSRPYKISESSKVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRECEHDLLQAALQWLTQQPEREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEGFIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSDDTCYLDAKSEQWVKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSKTVQVYDREADKWSRGVDLPKAIAGGSACVCALEPRPEDKKKKGKGKRHQDRGQ

Physical form

Solution in phosphate buffered saline, pH 7.4