Monoclonal Anti-TPMT antibody produced in mouse, clone 2H3, purified immunoglobulin, buffered aqueous solution

Not available outside of the UK & Ireland.

Biochem/physiol Actions

TPMT (Thiopurine S-methyltransferase) mainly mediates different catalytic S-methylation reaction such as 6-mercaptopurine and 6-thioguanine. It also participates in the metabolism of some drugs such as thiopurine drugs, which is largely influenced by TPMT polymorphisms. Deficiency in TPMT gene causes an autosomal recessive disorder, childhood acute lymphoblastic leukemia.

General description

This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q. (provided by RefSeq)

Immunogen

TPMT (AAH05339, 1 a.a. ~ 245 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.SequenceMDGTRTSLDIEEYSDTEVQKNQVLTLEEWQDKWVNGKTAFHQEQGHQLLKKHLDTFLKGKSGLRVFFPLCGKAVEMKWFADRGHSVVGVEISELGIQEFFTEQNLSYSEEPITEIPGTKVFKSSSGNISLYCCSIFDLPRTNIGKFDMIWDRGALVAINPGDRKCYADTMFSLLGKKFQYLLCVLSYDPTKHPGPPFYVPHAEIERLFGKICNIRRLEKVDAFEERHKSWGIDCLFEKLYLLTEK

Physical form

Solution in phosphate buffered saline, pH 7.4