Anti-PFKFB1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

Anti-PFKFB1 antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (PFKFB1) catalyzes the synthesis and degradation of fructose-2,6-bisphosphate. It plays a vital role in regulation of both glycolysis and gluconeogenesis. PFKFB1 also facilitates cell growth and apoptosis.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. (provided by RefSeq)

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (PFKFB1) is encoded by the gene mapped to human chromosome Xp11.21. The encoded protein is one among the four isoenzymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. PFKFB1 is expressed predominantly in liver.

Immunogen

PFKFB1 (NP_002616.1, 1 a.a. ~ 471 a.a) full-length human protein.SequenceMSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYLSHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPDYIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRTVYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSRMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY

Physical form

Solution in phosphate buffered saline, pH 7.4