Anti-Rpa1

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Replication protein A1 (RPA1) is essential in homology-directed recombinational repair. It plays a key role in nucleotide excision repair, mismatch repair, and base excision repair. RPA1 participates in DNA replication and recombination events. Decreased RPA1 levels can impair the activation of DNA damage checkpoint. Overexpression of the RPA1 gene affects the stability of the genome and results in 17p13.3 duplication syndrome.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Replication protein A1 (RPA1) is a constituent of the replication protein A (RPA) heterotrimer. RPA1 gene codes for RPA-70KD, the largest subunit of the RPA. RPA1 gene is located on human chromosome 17p13.3.

Immunogen

RPA1 (NP_002936.1, 1 a.a. ~ 616 a.a) full-length human protein.SequenceMVGQLSEGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLKSAEAVGVKIGNPVPYNEGLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGTQSKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNETSVMPCEDDHHLPTVQFDFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWGEDADKFDGSRQPVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFSSVATVVYLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNAAYLGELKDKNEQAFEEVFQNANFRSFIFRVRVKVETYNDESRIKATVMDVKPVDYREYGRRLVMSIRRSALM

Physical form

Solution in phosphate buffered saline, pH 7.4