Anti-Cux1

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Cut homeobox 1 (CUX1) binds to DNA and is involved in DNA repair. It stimulates the 8-oxoguanine-DNA glycosylase 1 (OGG1), a prime enzyme that acts on oxidative purine lesions and may have an indirect influence on radioresistance. Haploinsufficiency ofCUX1 may have an impact on developmental delay (DD) and mild intellectual disability(ID). The multiple isoforms of CUX1 may have implications on various physiological pathologies like polycystic kidney disease and tumor development. In cortical neurons, CUX1 may play a key role in regulating spine development, dendritic branching, and synapse formation. CUX1 is a tumor suppressor gene and its deletion is implicated in high-risk acute myeloid leukemia.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Cut homeobox 1 (CUX1) is a transcription factor that contains three major domains, which include four DNA binding domains, three CUT domains or repeats (C1, C2, and C3), and a Cut homeodomain. It is expressed in multiple isoforms.

Immunogen

CUX1 (AAH25422.1, 1 a.a. ~ 676 a.a) full-length human protein.SequenceMAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLNVYKRLIDVPDPVPALDLGQQLQLKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKNQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKVQSLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLSAKNSTLKQLEEKLKGQADYEEVKKELNILKSMEFAPSEGAGTQDAAKPLEVLLLEKNRSLQSESAALRISNSDLSGRCAELQVRITEAVATATEQRELIARLEQDLSIIQSIQRPDAEGAAEHRLEKIPEPIKEATALFYGPAAPASGALPEGQVDSLLSIISSQRERFRARNQELEAENRLAQHTLQALQSELDSLRADNVKLFEKIKFLQSYPGRGSGSDDTELRYSSQYEERLDPFSSFSKRERQRKYLSLSPWDKATLSMGRLVLSNKMARTIGFFYTLFLHCLVFLVLYKLAWSESMERDCATFCAKKFADHLHKFHENDNGAAAGDLWQ

Physical form

Solution in phosphate buffered saline, pH 7.4