Anti-Bcl3

Not available outside of the UK & Ireland.

Biochem/physiol Actions

B cell lymphoma 3 (BCL3) serves as a transcription co-activator. It modulates cyclin D1 transcription in human breast epithelial cells and keratinocytes. BCL3 stabilizes cellular Myc (c-Myc) protein and stimulates tumorigenesis in colorectal cancer cells. It can prevent apoptosis in MCF7AZ breast cancer cells. BCL3 plays a key role in the transcription of cellular inhibitors of apoptosis proteins 1 and 2 (cIAP1 and cIAP2) genes. It might be a possible biomarker in triple-negative breast cancer (TNBC) patients with the basal-like (BL1) subtype.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

B cell lymphoma 3 (BCL3), an oncogene, belongs to the inhibitor of the κ B (IκB) family. It is a nuclear protein with a transactivation domain. BCL3 gene is located on the human chromosome 19q13.

Immunogen

BCL3 (NP_005169.1, 1 a.a. ~ 446 a.a) full-length human protein.SequenceMDEGPVDLRTRPKAAGLPGAALPLRKRPLRAPSPEPAAPRGAAGLVVPLDPLRGGCDLPAVPGPPHGLARPEALYYPGALLPLYPTRAMGSPFPLVNLPTPLYPMMCPMEHPLSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQPDPSPDRSANTSPESSSRLSSNGLLSASPSSSPSQSPPRDPPGFPMAPPNFFLPSPSPPAFLPFAGVLRGPGRPVPPSPAPGGS

Physical form

Solution in phosphate buffered saline, pH 7.4