Monoclonal Anti-FABP3 antibody produced in mouse, clone 2F1, purified immunoglobulin, buffered aqueous solution

Not available outside of the UK & Ireland.

Biochem/physiol Actions

FABPs have been associated with diabetes, obesity, atherosclerosis and brain function. FABP-3 has a role in glucose and lipid metabolism. It also modulates polysaturated fatty acid uptake and metabolism in neurons. The protein has been associated with schizophrenia, Down’;s syndrome, Alzheimer′s disease and autism spectrum disorder.

General description

The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. (provided by RefSeq)

Immunogen

FABP3 (AAH07021, 1 a.a. ~ 133 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.SequenceMVDAFLGTWKLVDSKNFDDYMKSLGVGFATRQVASMTKPTTIIEKNGDILTLRTHSTFKNTEISFKLGVEFDETTADDRKVKSIVTLDGGKLVHLQKWDGQETTLVRELIDGKLILTLTHGTAVCTRTYEKEA

Physical form

Solution in phosphate buffered saline, pH 7.4