Monoclonal Anti-Mylip

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Myosin regulatory light chain interacting protein (MYLIP) might have a role in cholesterol uptake. It modulates the levels of low density lipoprotein receptor by controlling the ubiquitination of the intracellular tail of the receptor and its lysosomal degradation. Overexpression of the protein in mice livers has been shown to cause hypercholesterolemia and atherosclerosis.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Myosin regulatory light chain interacting protein (MYLIP) is an E3 ubiquitin ligase. The gene encoding it is localized on human chromosome 6p22.3.

Mouse monoclonal antibody raised against a full-length recombinant MYLIP.

Immunogen

MYLIP (AAH02860, 1 a.a. ~ 445 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.SequenceMLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQQMDGLAPYRLKLRVKFFVEPHLILQEQTRHIFFLHIKEALLAGHLLCSPEQAVELSALLAQTKFGDYNQNTAKYNYEELCAKELSSATLNSIVAKHKELEGTSQASAEYQVLQIVSAMENYGIEWHSVRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNVYLTVTKESGNSIVLLFKMISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLFLNENINLGKKYVFDIKRTSKEVYDHARRALYNAGVVDLVSRNNQSPSHSPLKSSESSMNCSSCEGLSCQQTRVLQEKLRKLKEAMLCMVCCEEEINSTFCPCGHTVCCESCAAQLQSCPVCRSRVEHVQHVYLPTHTSLLNLTVI

Physical form

Solution in phosphate buffered saline, pH 7.4