Monoclonal Anti-Cdc23

Not available outside of the UK & Ireland.

General description

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. (provided by RefSeq)

Immunogen

CDC23 (NP_004652.1, 491 a.a. ~ 591 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.SequenceIYSCGEIVEHLEESTAFRYLAQYYFKCKLWDEASTCAQKCCAFNDTREEGKALLRQILQLRNQGETPTTEVPAPFFLPASLSANNTPTRRVSPLNLSSVTP

Physical form

Solution in phosphate buffered saline, pH 7.4