Monoclonal Anti-Acot7. (N-Terminal)

Not available outside of the UK & Ireland.

Biochem/physiol Actions

ACOT7 (acyl-CoA thioesterase 7) is involved in fatty acid oxidation. It is a connecting link between metabolism of acyl-CoAs and cholesterol in neurons. Overexpression of this gene in macrophage cell line modulates the generation of prostaglandins D2 and E2, thereby making it a drug target in inflammatory diseases. ACOT7 has high specificity for arachido-258 noyl-CoA (AA-CoA). It might also be associated with mesial temporal lobe epilepsy (MTLE).

General description

This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. (provided by RefSeq)

Immunogen

ACOT7 (AAH17365, 1 a.a. ~ 338 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.SequenceMSGPDVETPSAIQICRIMRPDDANVAGNVHGGTILKMIEEAGAIISTRHCNSQNGERCVAALARVERTDFLSPMCIGEVAHVSAEITYTSKHSVEVQVNVMSENILTGAKKLTNKATLWYVPLSLKNVDKVLEVPPVVYSRQEQEEEGRKRYEAQKLERMETKWRNGDIVQPVLNPEPNTVSYSQSSLIHLVGPSDCTLHGFVHGGVTMKLMDEVAGIVAARHCKTNIVTASVDAINFHDKIRKGCVITISGRMTFTSNKSMEIEVLVDADPVVDSSQKRYRAASAFFTYVSLSQEGRSLPVPQLVPETEDEKKRFEEGKGRYLQMKAKRQGHAEPQP

Physical form

Solution in phosphate buffered saline, pH 7.4