Anti-IFNAR2 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution

Not available outside of the UK & Ireland.

Biochem/physiol Actions

The IFN (interferon) response is a part of the first line defense system against infection, which requires the binding of IFNs to the receptors (IFNAR1 and IFNAR2) for its activation. IFNAR2 (interferon αand βreceptor subunit 2) is associated with the JAK-STAT (Janus - signal transducer and activator of transcription) signaling pathway.

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General description

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. (provided by RefSeq)

Immunogen

IFNAR2 (AAH02793.1, 1 a.a. ~ 331 a.a) full-length human protein.SequenceMLLSQNAFIVRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHSIVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKKHKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAESAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLRQGLTKGWNAVAIHRCSHNALQSETPELKQSSCLSFPSSWDYKRASLCPSD

Physical form

Solution in phosphate buffered saline, pH 7.4