Anti-SLC3A2 antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

Not available outside of the UK & Ireland.

Biochem/physiol Actions

Solute carrier family 3 member 2 (SLC3A2) has a role in amino acid transport. It associates with integrins and modulates their signaling functions. The protein is involved in cell-to-cell fusion occurring between macrophages or trophoblasts. SLC3A2 is overexpressed in various cancers.

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General description

This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein with an alpha amylase domain. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. It associates with integrins and mediates integrin-dependent signaling related to normal cell growth and tumorigenesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. (provided by RefSeq)Solute carrier family 3 member 2 (SLC3A2) is a type II transmembrane glycoprotein which is widely expressed. It is expressed on the cell membrane and in some types of endosomes. The protein is part of the heterodimeric amino acid transporter family. The SLC3A2 gene is localized on human chromosome 11q13.

Immunogen

SLC3A2 (NP_001013269.1, 1 a.a. ~ 529 a.a) full-length human protein.SequenceMSQDTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVKIKVAEDEAEAAAAAKFTGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPAQKWWHTGALYRIGDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQIDPNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPHEGLLLRFPYAA

Physical form

Solution in phosphate buffered saline, pH 7.4