ANTI-UBIQUITIN(C-TERMINAL)

Not available outside of the UK & Ireland.

Application

Anti-ubiquitin antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

Ubiquitin plays a major role in protein degradation. Ubiquitin-mediated degradation of regulatory proteins has been implicated in the regulation of various processes, such as cell-cycle progression, signal transduction, transcriptional regulation, receptor down-regulation and endocytosis. Aberrations in the ubiquitin-mediated pathways contribute to malignant transformation.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Ubiquitin, also known as ubiquitin C (UBC), is a globular protein, encoded by the gene mapped to human chromosome 12q24.31. The encoded protein consists of 76 amino acids.

Immunogen

a synthetic peptide between 36-66 amino acids of human Ubiquitin, which is in the Ubiquitin-like 1 domain

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide