Anti-GHRH (center) antibody produced in rabbit, saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution

Not available outside of the UK & Ireland.

General description

GHRH belongs to the glucagon family and is a preproprotein that is produced in the hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this protein are a cause of dwarfism, while hypersecretion of the protein is a cause of gigantism.

Immunogen

GHRH (NP_066567, 58-90)This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human GHRH.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.