Anti-APS (center) antibody produced in rabbit, saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution

Not available outside of the UK & Ireland.

General description

APS is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.

Immunogen

APS (NP_066189, 256-289)This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human APS.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.