Anti-MCK10 antibody produced in rabbit, saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution

Not available outside of the UK & Ireland.

General description

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. MCK10 is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain.

Immunogen

MCK10 (NP_054699, )This antibody is generated from rabbits immunized with recombinant human MCK10 protein.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.