Anticorps Anti - BCR (N -term)produit dans le lapin, sulfate d'ammonium saturé (SAS) précipité, solution AQUEUSE tamponnée

Non disponible en dehors du Royaume-Uni et de l'Irlande

General description

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac.

Immunogen

BCR (NP_004318, 52-86)This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human BCR.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.