Anti-SOST (center) antibody produced in rabbit, Ig fraction of antiserum, buffered aqueous solution

Not available outside of the UK & Ireland.

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General description

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of the sclerostin gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Immunogen

SOST (NP_079513, 139-173)This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human SOST.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.