Anti-MSH3 (center) antibody produced in rabbit, saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution

Not available outside of the UK & Ireland.

General description

MSH3 is a component of the post-replicative DNA mismatch repair system (MMR). THis protein heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, it forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

Immunogen

MSH3 (NP_002430, 464-497)This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human MSH3.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.